Clinically relevant fatigue in men with hormonesensitive prostate cancer on long-term androgen deprivation therapy

Storey, D; McLaren, D; Atkinson, M; Butcher, I; Frew, L; Smyth, J; Sharpe, M

Journal article

Clinically relevant fatigue in men with hormonesensitive prostate cancer on long-term androgen deprivation therapy

Abstract:: Background: The purpose of the study was to determine the prevalence and associations of clinically relevant fatigue (CRF) in men with biochemically controlled prostate cancer on long-term androgen deprivation therapy (ADT). Patients and methods: One hundred and ninety-eight men were surveyed and the prevalence of CRF (Brief Fatigue Inventory score >3) determined. Associations with other measures (Hospital Anxiety and Depression Scale; International Prostate Symptom Score; European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire; Brief Pain Inventory worst pain; clinical and demographic information) were explored in univariate and multivariate analyses. Results: Eight-one per cent (160 of 198) of questionnaires were analysable. CRF prevalence was 43% (68 of 160). CRF associations included moderate/severe urinary symptoms, anxiety and medical co-morbidities; the strongest associations were depression [odds ratio (OR) 9.8, 95% confidence interval (CI) 4.3-22.8] and pain (OR 9.2, 95% CI 4.0-21.5). After controlling for other factors, the independent associations were depression (OR 4.7, 95% CI 1.6-14.0) and pain (OR 3.1, 95% CI 1.0-8.9). There was no association with age, disease burden or treatment duration. Conclusions: Two-fifths of men with biochemically controlled prostate cancer on long-term ADT report CRF that interferes with function. Management aimed at improving CRF should address depression and pain. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Storey, D., McLaren, D., Atkinson, M., Butcher, I., Frew, L., Smyth, J., & Sharpe, M. (2012). Clinically relevant fatigue in men with hormonesensitive prostate cancer on long-term androgen deprivation therapy. Annals of Oncology, 23(6), 1542–1549.

MLA Style

Storey, D, et al. “Clinically Relevant Fatigue in Men with Hormonesensitive Prostate Cancer on Long-Term Androgen Deprivation Therapy.” Annals of Oncology, vol. 23, no. 6, 2012, pp. 1542–49.

Chicago Style

Storey, D, D McLaren, M Atkinson, et al. 2012. “Clinically Relevant Fatigue in Men with Hormonesensitive Prostate Cancer on Long-Term Androgen Deprivation Therapy.” Annals of Oncology 23 (6): 1542–49.
Print