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Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Abstract:

Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ~50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci c...

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Publication status:
Published

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Publisher copy:
10.1016/j.ajhg.2013.12.016

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Journal:
American journal of human genetics
Volume:
94
Issue:
3
Pages:
349-360
Publication date:
2014-03-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:f0fa508a-3d28-46b2-91e7-bd97e1c1659f
Source identifiers:
449388
Local pid:
pubs:449388

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