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Emergence of the Asian 1 genotype of dengue Virus serotype 2 in viet Nam: in vivo fitness advantage and lineage replacement in South-East Asia

Abstract:

A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. To this end we determined the complete coding region sequence of 187 DENV-2 genomes and 68 E genes from viruses sampled from Vietnamese patients between 1995 and 2009. Strikingly, an episode of genotype replacement was observed, with Asian 1 lineage viruses entirely displacing the previously dominant Asian/American lineage viruses. This genotype ...

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Authors


Holmes, EC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
PLoS Neglected Tropical Diseases
Volume:
4
Issue:
7
Publication date:
2010-07-05
DOI:
URN:
uuid:f0f9f050-982e-4cdb-8d8b-4a8be43387ea
Source identifiers:
94615
Local pid:
pubs:94615
Language:
English

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