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The risk of finding focal cancer (less than 3 mm) remains high on re-biopsy of patients with persistently increased prostate specific antigen but the clinical significance is questionable.

Abstract:

PURPOSE: We evaluated the significance of focal prostate cancer found in sextant biopsies in men participating in a biennial prostate specific antigen (PSA) based screening program. MATERIALS AND METHODS: In 1995, 10000 men 50 to 65 years old were randomized to biennial screening with PSA testing. Sextant biopsies were recommended when total PSA was 3 ng/ml or greater at screening rounds 1 and 2, and 2.54 ng/ml or greater at subsequent screening rounds. Focal cancer was defined as total a co...

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Authors


Zackrisson, B More by this author
Bergdahl, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Lodding, P More by this author
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Journal:
The Journal of urology
Volume:
171
Issue:
4
Pages:
1500-1503
Publication date:
2004-04-05
DOI:
EISSN:
1527-3792
ISSN:
0022-5347
URN:
uuid:f0f27c1f-7615-4eae-80ce-9bfc728dc616
Source identifiers:
365992
Local pid:
pubs:365992

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