The risk of finding focal cancer (less than 3 mm) remains high on re-biopsy of patients with persistently increased prostate specific antigen but the clinical significance is questionable.

Journal article

PURPOSE: We evaluated the significance of focal prostate cancer found in sextant biopsies in men participating in a biennial prostate specific antigen (PSA) based screening program. MATERIALS AND METHODS: In 1995, 10000 men 50 to 65 years old were randomized to biennial screening with PSA testing. Sextant biopsies were recommended when total PSA was 3 ng/ml or greater at screening rounds 1 and 2, and 2.54 ng/ml or greater at subsequent screening rounds. Focal cancer was defined as total a co...

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Authors: Zackrisson, B; Aus, G; Bergdahl, S; Lilja, H; Lodding, P

• Journal: Journal of urology
• Volume: 171
• Issue: 4
• Pages: 1500-1503
• Publication date: 2004-04-01
• DOI: 10.1097/01.ju.0000118052.59597.83
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: Humans; Follow-Up Studies; Mass Screening; Prostatic Neoplasms; Risk Factors; Biopsy; Male; Aged; Prostate-Specific Antigen