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Role of p35/Cdk5 in preplate splitting in the developing cerebral cortex.

Abstract:

The earliest generated cells of the mammalian cerebral cortex form the preplate layer (PPL). The subsequently born cortical plate (CP) cells split this layer into the superficial layer I (LI) and the deep subplate (SP). The cellular and molecular mechanisms that underlie this event are unclear. To investigate the role of the cyclin-dependent kinase 5 (Cdk5) and its activator p35 in preplate splitting, we used Nissl staining, carbocyanine dye tracing, cell birthdating, and immunohistochemistry...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/bhj172

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Volume:
16 Suppl 1
Issue:
SUPPL. 1
Pages:
i35-i45
Publication date:
2006-07-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:f0ed0bdb-7b8a-4f82-8da4-3e980eafb6ed
Source identifiers:
114663
Local pid:
pubs:114663

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