FTO genetic variants and risk of obesity and type 2 diabetes: A meta-analysis of 28,394 Indians

Journal article

Objective To investigate the magnitude of association of FTO variants with obesity, type 2 diabetes (T2DM), and related traits among Asian Indians. Methods Random-effect meta-analysis was performed on pooled data from eight studies (n = 28,394) for obesity and related traits and six studies (n = 24,987) for assessment of T2DM risk in Indians where FTO variants were reported. Results The minor A-allele of the FTO variant rs9939609 was associated with increased risk of obesity (OR 1.15, 95% CI 1.08-1.21, p = 2.14 × 10-5), BMI (β = 0.30 kg/m2, 95% CI 0.21-0.38, p = 4.78 × 10-11) and other regional adiposity measurements [waist (β = 0.74 cm, 95% CI 0.49-0.99), HC (β = 0.52, 95% CI 0.26-0.78), and waist-hip ratio (WHR) (β = 0.002, 95% CI 0.001-0.004)] in Indians (p ≤ 0.001). An increased risk for T2DM (OR 1.11; 95% CI 1.04-1.19, p = 0.002) was observed, which attenuated when adjusted for age, gender, and BMI (OR 1.09; 95%CI 1.02-1.16, p = 0.01). Conclusions Our study provides evidence of association between common FTO variant and obesity risk among Indians with comparable effect sizes as in Caucasians. The attenuation of FTO-T2DM risk on BMI adjustment reinforces that BMI does not fully account for the adiposity effects among Asian Indians who are more centrally obese. Copyright © 2013 The Obesity Society.

Authors: Vasan, S; Karpe, F; Gu, H; Brismar, K; Fall, C

• Publisher: Nature Publishing Group
• Journal: Obesity
• Volume: 22
• Issue: 3
• Pages: 964-970
• Publication date: 2014-01-01
• DOI: 10.1002/oby.20606
• EISSN: 1930-739X
• ISSN: 1930-7381
• Language: English