Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation.

Journal article

The contraction-relaxation cycle of muscle cells translates into large movements of several filament systems in sarcomeres, requiring special molecular mechanisms to maintain their structural integrity. Recent structural and functional data from three filaments harboring extensive arrays of immunoglobulin-like domains - titin, filamin and myomesin--have, for the first time, unraveled a common function of their terminal domains: assembly and anchoring of the respective filaments. In each case,...

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Authors: Pinotsis, N; Abrusci, P; Djinović-Carugo, K; Wilmanns, M

• Publication status: Published
• Journal: Trends in biochemical sciences
• Volume: 34
• Issue: 1
• Pages: 33-39
• Publication date: 2009-01-01
• DOI: 10.1016/j.tibs.2008.09.009
• ISSN: 0968-0004
• Language: English
• Keywords: Sarcomeres; Animals; Muscle Proteins; Contractile Proteins; Protein Binding; Protein Structure, Secondary; Protein Kinases; Myosins; Humans; Biochemistry; Microfilament Proteins; Immunoglobulins; Protein Structure, Tertiary; Protein Interaction Mapping; Microscopy, Electron