A mathematical model for collagen fibre formation during foetal and adult dermal wound healing.

Journal article

Adult dermal wounds, in contrast to foetal wounds, heal with the formation of scar tissue. A crucial factor in determining the nature of the healed tissue is the ratio of collagen 1 to collagen 3, which regulates the diameter of collagen fibres. We develop a mathematical model which focuses on the stimulus for collagen synthesis due to the secretion of the different isoforms of the regulatory chemical transforming growth factor beta. Numerical simulations of the model lead to a value of this ...

Expand abstract

Authors: Dale, P; Sherratt, J; Maini, P

• Publication status: Published
• Journal: Proceedings. Biological sciences / The Royal Society
• Volume: 263
• Issue: 1370
• Pages: 653-660
• Publication date: 1996-05-01
• DOI: 10.1098/rspb.1996.0098
• EISSN: 1471-2954
• ISSN: 0962-8452
• Language: English
• Keywords: Transforming Growth Factor beta; Pregnancy; Collagen; Prenatal Injuries; Skin; Female; Models, Biological; Mathematics; Wound Healing; Fetus; Animals; Cicatrix