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An osteo-inductive bone matrix extract stimulates the in vitro conversion of mesenchyme into chondrocytes.

Abstract:

Urea and guanidine extracts of demineralized beef and rabbit bone matrix were assayed both in vivo and in vitro. One month following intramuscular implantation into mouse thighs, these extracts induced ectopic cartilage and bone. Seven days following continuous in vitro exposure to the same extracts, stage 24 chick limb bud mesenchymal cells in cultures had differentiated into greater numbers of chondrocytes than controls. These results suggest the feasibility of using limb bud mesenchymal ce...

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Publication status:
Published

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Publisher copy:
10.1007/bf02405378

Authors


Syftestad, GT More by this author
Triffitt, JT More by this author
Caplan, AI More by this author
Publisher:
Springer-Verlag
Journal:
Calcified tissue international
Volume:
36
Issue:
5
Pages:
625-627
Publication date:
1984-09-05
DOI:
EISSN:
1432-0827
ISSN:
0171-967X
URN:
uuid:f0d86bf6-6d15-4c17-a11e-cb3ede5e2985
Source identifiers:
108865
Local pid:
pubs:108865

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