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Regulation of tumor pH and the role of carbonic anhydrase 9.

Abstract:

The high metabolic rate required for tumor growth often leads to hypoxia in poorly-perfused regions. Hypoxia activates a complex gene expression program, mediated by hypoxia inducible factor 1 (HIF1alpha). One of the consequences of HIF1alpha activation is up-regulation of glycolysis and hence the production of lactic acid. In addition to the lactic acid-output, intracellular titration of acid with bicarbonate and the engagement of the pentose phosphate shunt release CO(2) from cells. Express...

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Publication status:
Published

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Publisher copy:
10.1007/s10555-007-9064-0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Vaughan-Jones, RD More by this author
Harris, AL More by this author
Journal:
Cancer metastasis reviews
Volume:
26
Issue:
2
Pages:
299-310
Publication date:
2007-06-05
DOI:
EISSN:
1573-7233
ISSN:
0167-7659
URN:
uuid:f0d77877-04b3-408f-8aa6-7cf341c7c703
Source identifiers:
106556
Local pid:
pubs:106556

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