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Synthesis of voltage−sensitive optical signals: Application to panoramic optical mapping

Abstract:
Fluorescent photon scattering is known to distort optical recordings of cardiac transmembrane potentials; however, this process is not well quantified, hampering interpretation of experimental data. This study presents a novel model, which accurately synthesizes fluorescent recordings over the irregular geometry of the rabbit ventricles. Using the model, the study aims to provide quantification of fluorescent signal distortion for different optical characteristics of the preparation and of the surrounding

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B. Rodriguez More by this author
JP Whiteley More by this author
N. Trayanova More by this author
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Journal:
BIOPHYSICAL JOURNAL
Volume:
90
Issue:
8
Pages:
2938-2945
Publication date:
2006-04-01
URN:
uuid:f0cba44f-020a-48c7-badb-1afebc95f31b
Local pid:
cs:4258

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