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A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure

Abstract:

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ajhg.2018.01.015

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Publisher:
Cell Press Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
102
Issue:
3
Pages:
375-400
Publication date:
2018-02-15
Acceptance date:
2018-01-18
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pubs id:
pubs:825521
URN:
uri:f0c9072b-33fe-4809-84ca-17e6ef2532f0
UUID:
uuid:f0c9072b-33fe-4809-84ca-17e6ef2532f0
Local pid:
pubs:825521

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