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Journal article

Incomplete response of inflammatory arthritis to TNF alpha blockade is associated with the Th17 pathway

Abstract:

Objectives: To establish if changes in Th1/Th17 cell populations previously reported in experimental arthritis occur in patients with rheumatoid arthritis (RA) treated with anti-tumour necrosis factor α (TNFα) agents, and whether the therapeutic response to anti-TNFα is compromised in patients and mice because of elevated Th17/IL-17 levels. Finally, to assess the efficacy of combined blockade of anti-TNFα and anti-IL-17 in experimental arthritis. Methods: A longitudinal study of two independe...

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Publication status:
Published

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Journal:
ANNALS OF THE RHEUMATIC DISEASES
Volume:
71
Issue:
10
Pages:
1741-1748
Publication date:
2012-10-01
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Source identifiers:
352887
Language:
English
Pubs id:
pubs:352887
UUID:
uuid:f0c0ef63-c900-444f-8897-58cf1114f496
Local pid:
pubs:352887
Deposit date:
2013-11-16

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