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A modular synthesis of conformationally preorganised extended β-strand peptidomimetics

Abstract:

A promising strategy for mediating protein-protein interactions is the use of non-peptidic mimics of secondary structural protein elements, such as the α-helix. Recent work has expanded the scope of this approach by providing proof-of-principle scaffolds that are conformationally biased to mimic the projection of side-chains from one face of another common secondary structural element-the β-strand. Herein, we present a synthetic route that has key advantages over previous work: monomers beari...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/chem.201501366

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
University of Oxford More from this funder
Publisher:
Wiley Publisher's website
Journal:
Chemistry - A European Journal Journal website
Volume:
21
Issue:
42
Pages:
14699-14702
Publication date:
2015-08-17
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
URN:
uuid:f0bdec64-6f4f-4eca-839b-7bb8cc2ed93c
Source identifiers:
567674
Local pid:
pubs:567674

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