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Rotavirus mRNAS are released by transcript-specific channels in the double-layered viral capsid.

Abstract:

Rotaviruses are the single most common cause of fatal and severe childhood diarrheal illness worldwide (>125 million cases annually). Rotavirus shares structural and functional features with many viruses, such as the presence of segmented double-stranded RNA genomes selectively and tightly packed with a conserved number of transcription complexes in icosahedral capsids. Nascent transcripts exit the capsid through 12 channels, but it is unknown whether these channels specialize in specific ...

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Publisher copy:
10.1073/pnas.1220345110

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
29
Pages:
12042-12047
Publication date:
2013-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f0bd3658-2c43-4ad4-894f-0aa45fefb2a4
Source identifiers:
410862
Local pid:
pubs:410862

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