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Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.

Abstract:

Chromosomal translocation t(9;11)(p22;q23) in acute myeloid leukemia fuses the MLL and AF9 genes. We have inactivated the murine homologue of AF9 to elucidate its normal role. No effect on hematopoiesis was observed in mice with a null mutation of Af9. However, an Af9 null mutation caused perinatal lethality, and homozygous mice exhibited anomalies of the axial skeleton. Both the cervical and thoracic regions were affected by anterior homeotic transformation. Strikingly, mice lacking function...

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Publisher copy:
10.1128/mcb.22.20.7313-7324.2002

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Journal:
Molecular and cellular biology More from this journal
Volume:
22
Issue:
20
Pages:
7313-7324
Publication date:
2002-10-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306

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