Genetic disorders associated with cancer predisposition and genomic instability.

Journal article

Genomic instability in its broadest sense is a feature of virtually all neoplastic cells. In addition to the mutations and/or gene amplifications that appear to be a prerequisite for the acquisition of a neoplastic phenotype, human cancers exhibit other "markers" of genomic instability--in particular, a high degree of aneuploidy. Indeed, many studies have shown that aneuploidy is an almost invariant feature of cancer cells, and it has been argued by some that the emergence of aneuploid cells ...

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Authors: Vessey, C; Norbury, C; Hickson, I

• Publication status: Published
• Journal: Progress in nucleic acid research and molecular biology
• Volume: 63
• Pages: 189-221
• Publication date: 1999-01-01
• ISSN: 0079-6603
• Language: English
• Keywords: Animals; Genetic Diseases, Inborn; Genetic Predisposition to Disease; Humans; Neoplasms