Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.

Journal article

Recent studies implicated the existence of adult lymphoid-primed multipotent progenitors (LMPPs) with little or no megakaryocyte-erythroid potential, questioning common myeloid and lymphoid progenitors as obligate intermediates in hematopoietic stem cell (HSC) lineage commitment. However, the existence of LMPPs remains contentious. Herein, global and single-cell analyses revealed a hierarchical organization of transcriptional lineage programs, with downregulation of megakaryocyte-erythroid ge...

Expand abstract

Authors: Månsson, R; Hultquist, A; Luc, S; Yang, L; Anderson, K

• Publication status: Published
• Journal: Immunity
• Volume: 26
• Issue: 4
• Pages: 407-419
• Publication date: 2007-04-01
• DOI: 10.1016/j.immuni.2007.02.013
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: Cell Lineage; Multipotent Stem Cells; Fetus; Lymphocytes; Gene Expression Profiling; Mice; Transcription, Genetic; Adult Stem Cells; Gene Expression Regulation, Developmental; Fetal Development; Animals