Angiotensin I conversion and coronary constriction by angiotensin II in ischemic and hypoxic isolated rat hearts.

Journal article

Dose-response curves of angiotensin I (AI, 1.0-1000.0 pmol) and angiotensin II (AII, 1.25-1250.00 pmol) were obtained in isolated rat hearts subjected to control conditions, mild hypoxia (PO2 = 145 mm Hg), reoxygenation, ischemic (perfusion pressure = 35 mm Hg) and reperfusion. Both AI and AII caused dose-dependent coronary flow (CF) of 26 +/- 3 and 27 +/- 2%, respectively. The effects of both AI and AII were substantially attenuated during hypoxia, but were fully restored upon reoxygenation....

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Authors: Tian, R; Neubauer, S; Pulzer, F; Haas, U; Ertl, G

• Journal: European journal of pharmacology
• Volume: 203
• Issue: 1
• Pages: 71-77
• Publication date: 1991-10-01
• DOI: 10.1016/0014-2999(91)90792-o
• EISSN: 1879-0712
• ISSN: 0014-2999
• Language: English
• Keywords: Coronary Disease; Heart; Coronary Vessels; Rats; Vasoconstriction; Animals; Male; Rats, Inbred Strains; Anoxia; Coronary Circulation; Angiotensin I; Saralasin; Angiotensin II