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Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.

Abstract:

Tumor-associated macrophages (TAMs) produce angiogenic factors and in breast cancer are associated with high vascular grade and poor survival. TAMs preferentially migrate to hypoxic areas within tumors and strongly express hypoxia-inducible factor (HIF)-2 alpha. This study examined whether HIF-2 alpha was involved in TAM angiogenic activation by correlating its expression with tumor microvessel density as a marker of angiogenesis, and other tumor variables, in a series of human primary invasi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
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Journal:
Cancer research
Volume:
62
Issue:
5
Pages:
1326-1329
Publication date:
2002-03-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:f0ae9a95-ce31-4a7a-a0d6-80540eaf2e2c
Source identifiers:
119402
Local pid:
pubs:119402

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