Generation of mice with a conditional Foxp2 null allele.

Journal article

Disruptions of the human FOXP2 gene cause problems with articulation of complex speech sounds, accompanied by impairment in many aspects of language ability. The FOXP2/Foxp2 transcription factor is highly similar in humans and mice, and shows a complex conserved expression pattern, with high levels in neuronal subpopulations of the cortex, striatum, thalamus, and cerebellum. In the present study we generated mice in which loxP sites flank exons 12-14 of Foxp2; these exons encode the DNA-bindi...

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Authors: French, C; Groszer, M; Preece, C; Coupe, A; Rajewsky, K

• Publication status: Published
• Journal: Genesis (New York, N.Y. : 2000)
• Volume: 45
• Issue: 7
• Pages: 440-446
• Publication date: 2007-07-01
• DOI: 10.1002/dvg.20305
• EISSN: 1526-968X
• ISSN: 1526-954X
• Language: English
• Keywords: Repressor Proteins; Mice; Nervous System Diseases; Forkhead Transcription Factors; Mice, Inbred C57BL; Female; Male; Mice, Knockout; Animals; Cerebellum