ACTH, LPH, and beta-endorphin secretion from perfused isolated human pituitary tumour cells in vitro.

Journal article

We report the chromatographic characterization of the ACTH- and LPH-related peptides released from isolated cells prepared from human ACTH-secreting pituitary tumours obtained at surgery (trans-sphenoidal hypophysectomy) from 2 patients with pituitary-dependent Cushing's disease and 2 patients with Nelson's syndrome. The dynamic release of these peptides in response to various stimuli, including rat stalk-median eminence extract (SME) and synthetic arginine vasopressin (AVP) was studied.

Authors: Gillies, G; Ratter, S; Grossman, A; Gaillard, R; Lowry, P

• Publication status: Published
• Journal: Hormone research
• Volume: 13
• Issue: 4-5
• Pages: 280-290
• Publication date: 1980-01-01
• DOI: 10.1159/000179295
• EISSN: 1423-0046
• ISSN: 0301-0163
• Language: English
• Keywords: Animals; Humans; Rats; Perfusion; Endorphins; Arginine Vasopressin; beta-Lipotropin; Pituitary Gland, Anterior; Tissue Extracts; Cross Reactions; Pituitary Neoplasms; Kinetics; Hypothalamus; Radioimmunoassay; Adrenocorticotropic Hormone