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Structure and self-assembly of the calcium binding matrix protein of human metapneumovirus

Abstract:

The matrix protein (M) of paramyxoviruses plays a key role in determining virion morphology by directing viral assembly and budding. Here, we report the crystal structure of the human metapneumovirus M at 2.8 Å resolution in its native dimeric state. The structure reveals the presence of a high-affinity Ca binding site. Molecular dynamics simulations (MDS) predict a secondary lower-affinity site that correlates well with data from fluorescence-based thermal shift assays. By combining small-an...

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Publisher copy:
10.1016/j.str.2013.10.013

Authors


Huiskonen, JT More by this author
Grimes, JM More by this author
Journal:
Structure
Volume:
22
Issue:
1
Pages:
136-148
Publication date:
2014-01-07
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:f09a3774-8df2-4337-b1c2-0c4cb253e9bb
Source identifiers:
447224
Local pid:
pubs:447224

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