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Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors.

Abstract:

This review summarises some of the knowledge we have about Crk and Grb2 family adaptor protein signalling in health and disease and outlines the current status and the challenges still remaining in the development of efficient and selective inhibitors of their protein - protein interactions. It also highlights briefly some recent successes and problems of inhibitors for proteins that functionally interact with Crk and Grb2 family adaptors, as well as opportunities, which may arise from combin...

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Publication status:
Published

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Publisher copy:
10.2174/138161206775474369

Authors


Feller, SM More by this author
Lewitzky, M More by this author
Journal:
Current pharmaceutical design
Volume:
12
Issue:
5
Pages:
529-548
Publication date:
2006
DOI:
EISSN:
1873-4286
ISSN:
1381-6128
URN:
uuid:f0994fd9-5680-44f2-b337-3ddc91edbd62
Source identifiers:
178412
Local pid:
pubs:178412

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