Journal article icon

Journal article

Microsatellite instability regulates transcription factor binding and gene expression.

Abstract:

Microsatellites are tandemly repeated simple sequence DNA motifs widely prevalent in eukaryotic and prokaryotic genomes. In pathogenic bacteria, instability of these hypermutable loci through slipped-strand mispairing mediates the high-frequency reversible switching of phenotype expression, i.e., phase variation. Phase-variable expression of NadA, an outer membrane protein and adhesin of the pathogen Neisseria meningitidis, is mediated by changes in the number of TAAA repeats located upstream...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.0406805102

Authors


Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
10
Pages:
3800-3804
Publication date:
2005-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f090c41e-ef77-405f-89c9-ea482cb90d39
Source identifiers:
115604
Local pid:
pubs:115604

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP