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Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

Abstract:

Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional response. Here, we show that NEAT1 long non-coding RNA (lncRNA) is a direct transcriptional target of HIF in many breast cancer cell lines and in solid tumors. Unlike previously descri...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/onc.2014.378

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Oncogene Journal website
Publication date:
2014-11-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:f08a0a8d-ded1-4adf-88e4-94629c5931f7
Source identifiers:
491291
Local pid:
pubs:491291
Language:
English

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