Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

Journal article

OBJECTIVES: Despite recent major advances in the understanding of the pathogenesis of rheumatoid arthritis, with tumour necrosis factor-alpha (TNFalpha) established as a major therapeutic target, comparatively little is known about the mediators involved in the destructive and inflammatory pathways in osteoarthritis (OA). Recently, it has become appreciated that an inflammatory synovitis contributes not only to the signs and symptoms of osteoarthritis, but also to disease progression. Here, w...

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Authors: Amos, N; Lauder, S; Evans, A; Feldmann, M; Bondeson, J

• Publication status: Published
• Journal: Rheumatology (Oxford, England)
• Volume: 45
• Issue: 10
• Pages: 1201-1209
• Publication date: 2006-10-01
• DOI: 10.1093/rheumatology/kel078
• EISSN: 1462-0332
• ISSN: 1462-0324
• Language: English
• Keywords: Humans; T-Lymphocytes; Metalloproteases; Adenoviridae; I-kappa B Proteins; Osteoarthritis; Cells, Cultured; Mitogen-Activated Protein Kinase 1; Synovial Membrane; Gene Expression; Inflammation Mediators; Cytokines; Macrophages; NF-kappa B; Transduction, Genetic; Apoptosis