Inter-species horizontal transfer resulting in core-genome and niche-adaptive variation within Helicobacter pylori.

Journal article

BACKGROUND: Horizontal gene transfer is central to evolution in most bacterial species. The detection of exchanged regions is often based upon analysis of compositional characteristics and their comparison to the organism as a whole. In this study we describe a new methodology combining aspects of established signature analysis with textual analysis approaches. This approach has been used to analyze the two available genome sequences of H. pylori. RESULTS: This gene-by-gene analysis reveals ...

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Authors: Saunders, N; Boonmee, P; Peden, J; Jarvis, SA

• Publication status: Published
• Journal: BMC genomics
• Volume: 6
• Pages: 9
• Publication date: 2005-01-01
• DOI: 10.1186/1471-2164-6-9
• EISSN: 1471-2164
• ISSN: 1471-2164
• Language: English
• Keywords: Gene Deletion; Gene Transfer, Horizontal; Conserved Sequence; Open Reading Frames; Models, Statistical; Genetic Variation; Protein Structure, Tertiary; Membrane Proteins; Genes, Bacterial; Species Specificity; Gene Expression Regulation; Bacteriophages; Molecular Sequence Data; Helicobacter pylori; Evolution, Molecular; Escherichia coli Proteins; Genome; DNA Polymerase III; Integrases; Genome, Bacterial; Adaptation, Physiological; Sequence Analysis, DNA; Virulence; Models, Genetic