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Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.

Abstract:

Neonatal hypoxic ischaemic (HI) injury frequently causes neural impairment in surviving infants. Our knowledge of the underlying molecular mechanisms is still limited. Protein deimination is a post-translational modification caused by Ca(+2) -regulated peptidylarginine deiminases (PADs), a group of five isozymes that display tissue-specific expression and different preference for target proteins. Protein deimination results in altered protein conformation and function of target proteins, and ...

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Publisher copy:
10.1111/jnc.12744

Authors


Rocha-Ferreira, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Bennett, K More by this author
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Journal:
Journal of neurochemistry
Volume:
130
Issue:
4
Pages:
555-562
Publication date:
2014-08-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:f078d467-7f78-4282-b0f0-c2d6af149574
Source identifiers:
487186
Local pid:
pubs:487186

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