Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

Journal article

We used gene targeting techniques to produce mice lacking the invariant chain associated with major histocompatibility complex (MHC) class II molecules. Cells from these mice show a dramatic reduction in surface class II, resulting from both defective association of class II alpha and beta chains and markedly decreased post-Golgi transport. The few class II alpha/beta heterodimers reaching the cell surface behave as if empty or occupied by an easily displaced peptide, and display a distinct s...

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Authors: Bikoff, E; Huang, L; Episkopou, V; van Meerwijk, J; Germain, R

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 177
• Issue: 6
• Pages: 1699-1712
• Publication date: 1993-06-01
• DOI: 10.1084/jem.177.6.1699
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Mutation; Cells, Cultured; Histocompatibility Antigens Class II; CD4-Positive T-Lymphocytes; Biological Transport; Animals; Mice, Inbred C57BL; Hematopoietic Stem Cells; Peptide Fragments; Antigens, Differentiation, B-Lymphocyte; Antigens, Surface; Mice