Colorectal cancer prognosis: is it all mutation, mutation, mutation?

Journal article

For the 500,000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts. K-ras, but not p53 or APC, mutations appear to be associated with poorer overall survival in colorectal cancer patients.

Authors: Hassan, A; Paraskeva, C

• Publication status: Published
• Journal: Gut
• Volume: 54
• Issue: 9
• Pages: 1209-1211
• Publication date: 2005-09-01
• DOI: 10.1136/gut.2005.070946
• EISSN: 1468-3288
• ISSN: 0017-5749
• Language: English
• Keywords: Polymorphism, Restriction Fragment Length; Female; Genes, ras; Survival Rate; Humans; DNA, Neoplasm; Male; Colorectal Neoplasms; Middle Aged; Genes, p53; Prognosis; Mutation; Aged; Genes, APC