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Aggrecanases in cartilage matrix breakdown

Abstract:

In rheumatoid arthritis and osteoarthritis, the loss of extracellular matrix macromolecules, aggrecan and collagens exceeds new production, resulting in serious joint impairment. The primary cause of this loss is due to elevated proteolytic enzyme activities. Recent studies have suggested that the enzymes called 'aggrecanases' that specifically cleaves the Glu373-Ala 274 of the aggrecan core protein play a key role in the early phase of cartilage destruction. Two aggrecanases have been purifi...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Connective Tissue
Volume:
33
Issue:
1
Pages:
27-32
Publication date:
2001
ISSN:
0916-572X
URN:
uuid:f06ccf24-c0ba-4256-b310-164cfb0c2fce
Source identifiers:
227557
Local pid:
pubs:227557

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