Adjusting therapeutic dosage regimens to optimise the balance of benefit to harm.
Dosage regimens should generally be individualised, depending on features of the patient that can alter the drug's pharmacokinetics (disposition in the body) or pharmacodynamics (therapeutic and adverse effects). It is usually good practice to start with a low dose, gradually increasing it according to response; a loading dose can produce a response more quickly if necessary. The most important factors that alter drug pharmacokinetics are renal insufficiency and liver disease. The most import...Expand abstract
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