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Neuroprotective effects of omega-Aga-IVA against in vitro ischaemia in the rat hippocampal slice.

Abstract:

Excessive accumulation of Ca2+ in neurones and glutamate release are involved in neuropathological processes, including ischaemia. We investigated the neuroprotective effects of the Ca2+ channel antagonist, omega-Aga-IVA, in CA1 pyramidal neurones in rat hippocampal slices following an in vitro hypoxic-hypoglycaemic insult. Following this insult, evoked post-synaptic response amplitudes decreased from 3.7 +/- 0.5 mV to 0.6 +/- 0.2 mV and the CA1 neurones appeared dead using a live/dead fluore...

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Publication status:
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Authors


Monette, R More by this author
Mealing, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
Neuroreport
Volume:
6
Issue:
12
Pages:
1617-1620
Publication date:
1995-08-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:f06434b3-1b6d-403c-be3e-3b453f8c17a3
Source identifiers:
80187
Local pid:
pubs:80187

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