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Physical training for McArdle disease.

Abstract:

McArdle disease is a rare metabolic myopathy caused by a complete absence of the enzyme muscle glycogen phosphorylase. Affected people experience symptoms of fatigue and cramping within minutes of exercise and are at risk for acute muscle injury (rhabdomyolysis) and acute renal failure. If the first few minutes of exercise are paced, a 'second wind' will occur enabling exercise to continue. This is due to mobilisation and utilisation of alternative fuel substrates. Aerobic training appears to...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Cochrane database of systematic reviews (Online)
Volume:
12
Publication date:
2011-01-01
EISSN:
1469-493X
URN:
uuid:f061fe0f-9c3f-46bf-a885-2e802a231784
Source identifiers:
313655
Local pid:
pubs:313655
Language:
English

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