Mathematical models for somite formation

Journal article

Somitogenesis is the process of division of the anterior–posterior vertebrate embryonic axis into similar morphological units known as somites. These segments generate the pre-pattern which guides formation of the vertebrae, ribs and other associated features of the body trunk. In this work, we review and discuss a series of mathematical models which account for different stages of somite formation. We begin by presenting current experimental information and mechanisms explaining somite formation, highlighting features which will be included in the models. For each model we outline the mathematical basis, show results of numerical simulations, discuss their shortcomings and avenues for future exploration. We conclude with a brief discussion of the state of modelling in the field and current challenges which need to be overcome in order to further our understanding in this area.

Authors: Baker, R; Schnell, S; Maini, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Current Topics in Developmental Biology
• Volume: 81
• Pages: 183-203
• Publication date: 2007-11-18
• DOI: 10.1016/S0070-2153(07)81006-4
• Keywords: SBTMR