Journal article icon

Journal article

Inhibition of the alpha-L-arabinofuranosidase III of Monilinia fructigena by 1,4-dideoxy-1,4-imino-L-threitol and 1,4-dideoxy-1,4-imino-L-arabinitol.

Abstract:

1. 1,4-Dideoxy-1,4-imino-L-threitol was synthesized and the synthesis of 1,4-dideoxy-1,4-imino-L-arabinitol was improved. 2. Both compounds are competitive inhibitors of Monilinia fructigena alpha-L-arabinofuranosidase III, the additional hydroxymethyl group in the arabinitol contributing about 17.8 kj/mol (4.25 kcal/mol) to the Gibbs free energy of binding. 3. The affinities (1/Ki) of both compounds vary with pH in a classical bell-shaped way, the pKa value being that of the acid-catalytic g...

Expand abstract
Publication status:
Published

Actions


Authors


Axamawaty, MT More by this author
Hannah, KA More by this author
Namgoong, SK More by this author
Sinnott, ML More by this author
Journal:
The Biochemical journal
Volume:
266
Issue:
1
Pages:
245-249
Publication date:
1990-02-05
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:f060c789-6682-4bd6-9dc1-b21bb61f87bc
Source identifiers:
43295
Local pid:
pubs:43295

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP