Journal article
Reliability of the global cortical atrophy visual rating scale applied to computed tomography versus magnetic resonance imaging scans in acute stroke
- Abstract:
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Introduction: Research using magnetic resonance imaging (MRI) suggests regional cerebral atrophy measures (e.g., frontal lobe, temporal lobe) may predict post-stroke outcomes. Clinical CT scans have excellent potential for use in research but it is unclear whether regional atrophy measures from CT are reliable compared to MRI reference standards.
Methods: We used the Global Cortical Atrophy (GCA) scale to investigate reliability of atrophy measures on CT versus MRI scans from stroke patients originally recruited to the Oxford Cognitive Screening programme. Two raters provided standardised visual ratings at two timepoints. Weighted Kappa statistics assessed the reliability of regional atrophy scores. Spearman’s correlation and a two-way repeated measures ANOVA assessed the reliability of the total score.
Results: On clinically acquired neuroimaging from 98 stroke patients (mean/SD age = 70.97/11.99, 42 female, 84 ischaemic stroke), regional GCA scores on CT versus MRI showed fair to almost perfect intra-rater agreement (κ = .50–.87), substantial to almost perfect intra-rater agreement on CT (κ = .67–.88), and moderate to almost perfect intra-rater reliability on MRI (κ = .50–.89). Regional GCA scores showed mostly moderate to substantial inter-rater reliability on both CT and MRI (κ = .43–.69), except the temporal horns and parieto-occipital region. There was a strong correlation between total GCA scores on CT and MRI (r (96) = .87–.88, p < .001).
Conclusions: These results support the use of cerebral atrophy measures from CT in clinical research, as visual ratings showed generally good agreement between CT and MRI, between raters, and between timepoints.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 752.4KB, Terms of use)
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- Publisher copy:
- 10.1007/s10072-023-07113-z
Authors
- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- NIHR RCF 21/040
- Publisher:
- Springer
- Journal:
- Neurological Sciences More from this journal
- Volume:
- 45
- Issue:
- 4
- Pages:
- 1549-1556
- Publication date:
- 2023-11-01
- Acceptance date:
- 2023-10-01
- DOI:
- EISSN:
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1590-3478
- ISSN:
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1590-1874
- Pmid:
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37910322
- Language:
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English
- Keywords:
- Pubs id:
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1560693
- Local pid:
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pubs:1560693
- Deposit date:
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2025-04-23
- ARK identifier:
Terms of use
- Copyright holder:
- Hobden et al.
- Copyright date:
- 2023
- Rights statement:
- Copyright © 2023, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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