Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.

Nilsson, T; Arkhammar, P; Rorsman, P; Berggren, PO

Abstract:

The effects of galanin and somatostatin on insulin release, membrane potential, and cytoplasmic free Ca2+ concentration [( Ca2+]i) were investigated using beta-cells isolated from obese hyperglycemic mice. Whereas insulin release was measured in a column perifusion system, membrane potential and [Ca2+]i were measured with the fluorescent indicators bisoxonol (bis-(1,3-diethylthiobarbiturate)trimethineoxonol) and quin 2, in cell suspensions in a cuvette. Galanin (16 nM) and somatostatin (400 n...

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APA Style

Nilsson, T., Arkhammar, P., Rorsman, P., & Berggren, P. O. (1989). Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration. The Journal of Biological Chemistry, 264(2), 973–980.

MLA Style

Nilsson, T., et al. “Suppression of Insulin Release by Galanin and Somatostatin Is Mediated by a G-Protein. An Effect Involving Repolarization and Reduction in Cytoplasmic Free Ca2+ Concentration.” The Journal of Biological Chemistry, vol. 264, no. 2, The Journal of biological chemistry, 1989, pp. 973–80.

Chicago Style

Nilsson, T, P Arkhammar, P Rorsman, and PO Berggren. 1989. “Suppression of Insulin Release by Galanin and Somatostatin Is Mediated by a G-Protein. An Effect Involving Repolarization and Reduction in Cytoplasmic Free Ca2+ Concentration.” The Journal of Biological Chemistry 264 (2): 973–80.
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