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Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.

Abstract:

The effects of galanin and somatostatin on insulin release, membrane potential, and cytoplasmic free Ca2+ concentration [( Ca2+]i) were investigated using beta-cells isolated from obese hyperglycemic mice. Whereas insulin release was measured in a column perifusion system, membrane potential and [Ca2+]i were measured with the fluorescent indicators bisoxonol (bis-(1,3-diethylthiobarbiturate)trimethineoxonol) and quin 2, in cell suspensions in a cuvette. Galanin (16 nM) and somatostatin (400 n...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
264
Issue:
2
Pages:
973-980
Publication date:
1989-01-05
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:f04d2323-1844-48e3-aa57-3f5ba897bfed
Source identifiers:
25585
Local pid:
pubs:25585

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