Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development.

Journal article

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed by inactivation of the p16(Ink4a) gene. Melanomas also frequently exhibit constitutive activation of the Wnt/beta-catenin pathway that is presumed to induce proliferation, as it does in carcinomas. We show here that, contrary to expectations, sta...

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Authors: Delmas, V; Beermann, F; Martinozzi, S; Carreira, S; Ackermann, J

• Publication status: Published
• Journal: Genes and development
• Volume: 21
• Issue: 22
• Pages: 2923-2935
• Publication date: 2007-11-01
• DOI: 10.1101/gad.450107
• EISSN: 1549-5477
• ISSN: 0890-9369
• Language: English
• Keywords: Melanoma; Crosses, Genetic; Cell Line, Transformed; Melanocytes; Animals; Chromatin Immunoprecipitation; Mice; beta Catenin; Electrophoretic Mobility Shift Assay; Mice, Transgenic; Transfection; Luciferases; Humans; Gene Silencing; Genes, ras; Cells, Cultured; beta-Galactosidase; Cyclin-Dependent Kinase Inhibitor p16; Cell Transformation, Neoplastic