Stroke: a double-edged sword for cleaving clots?

Journal article

The discovery that tissue plasminogen activator can promote neuronal degeneration has uncovered a novel pathway leading to neuronal cell death and raises important issues concerning the use of tissue plasminogen activator as a thrombolytic therapy for stroke.

Authors: Anthony, D; Perry, V

• Publication status: Published
• Journal: Current biology : CB
• Volume: 8
• Issue: 8
• Pages: R274-R277
• Publication date: 1998-04-01
• DOI: 10.1016/s0960-9822(98)70171-x
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Cell Death; Humans; Animals; Thrombolytic Therapy; Mice; Neurons; Microglia; Tissue Plasminogen Activator; Brain Ischemia