Failure to prevent selective CA1 neuronal death and reduce cortical infarction following cerebral ischemia with inhibition of nitric oxide synthase.

Journal article

We investigated the putative role of nitric oxide in the expression of neuronal injury following both transient severe forebrain ischemia (CA1 neuronal injury) and transient or permanent middle cerebral artery occlusion (neocortical pannecrosis). Using the four-vessel occlusion model and increasing doses of N-omega-nitro-L-arginine, 2-40 mg/kg, we were unable to demonstrate any reduction in the percentage of CA1 cells injured following 10 min of transient severe forebrain ischemia followed by...

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Authors: Buchan, A; Gertler, S; Huang, Z; Li, H; Chaundy, K

• Publication status: Published
• Journal: Neuroscience
• Volume: 61
• Issue: 1
• Pages: 1-11
• Publication date: 1994-07-01
• DOI: 10.1016/0306-4522(94)90054-x
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Blood Gas Analysis; Rats, Wistar; Arginine; Necrosis; Rats, Inbred SHR; Rats; Animals; Male; Cell Death; Nitroarginine; Ischemic Attack, Transient; Cerebral Infarction; Nitric Oxide Synthase; Cerebral Arteries; Neurons; Blood Pressure; Amino Acid Oxidoreductases