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Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.

Abstract:

The mechanical properties of the extracellular matrix have recently been shown to promote myofibroblast differentiation and lung fibrosis. Mechanisms by which matrix stiffness regulates myofibroblast differentiation are not fully understood. The goal of this study was to determine the intrinsic mechanisms of mechanotransduction in the regulation of matrix stiffness-induced myofibroblast differentiation. A well established polyacrylamide gel system with tunable substrate stiffness was used in ...

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Publisher copy:
10.1165/rcmb.2012-0050oc

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Journal:
American journal of respiratory cell and molecular biology
Volume:
47
Issue:
3
Pages:
340-348
Publication date:
2012-09-05
DOI:
EISSN:
1535-4989
ISSN:
1044-1549
URN:
uuid:f038a735-e380-41a2-a067-850258f4f74e
Source identifiers:
322942
Local pid:
pubs:322942

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