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Insights into protein kinase regulation and inhibition by large scale structural comparison.

Abstract:

Protein structure determination of soluble globular protein domains has developed into an efficient routine technology which can now be applied to generate and analyze structures of entire human protein families. In the kinase area, several kinase families still lack comprehensive structural analysis. Nevertheless, Structural Genomics (SG) efforts contributed more than 40 kinase catalytic domain structures during the past 4 years providing a rich resource of information for large scale compar...

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Publication status:
Published

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Authors


Eswaran, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
Biochimica et biophysica acta
Volume:
1804
Issue:
3
Pages:
429-432
Publication date:
2010-03-05
DOI:
ISSN:
0006-3002
URN:
uuid:f033850b-959f-4482-b322-eacc15351974
Source identifiers:
34949
Local pid:
pubs:34949

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