Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Journal article

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice...

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Authors: Harding, B; Lemos, M; Reed, A; Walls, G; Jeyabalan, J

• Publication status: Published
• Journal: Endocrine-related cancer
• Volume: 16
• Issue: 4
• Pages: 1313-1327
• Publication date: 2009-12-01
• DOI: 10.1677/erc-09-0082
• EISSN: 1479-6821
• ISSN: 1351-0088
• Language: English
• Keywords: RNA, Messenger; Male; Parathyroid Neoplasms; Female; Corticosterone; Immunoenzyme Techniques; Blotting, Western; Reverse Transcriptase Polymerase Chain Reaction; Mice, Inbred C57BL; Pituitary Neoplasms; Adrenal Gland Neoplasms; Hypercalcemia; Hypophosphatemia; Pancreatic Neoplasms; Animals; Loss of Heterozygosity; Multiple Endocrine Neoplasia Type 1; Proto-Oncogene Proteins; Mice, Knockout; Mice