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Approximate likelihood methods for estimating local recombination rates

Abstract:

There is currently great interest in understanding the way in which recombination rates vary, over short scales, across the human genome. Aside from inherent interest, an understanding of this local variation is essential for the sensible design and analysis of many studies aimed at elucidating the genetic basis of common diseases or of human population histories. Standard pedigree-based approaches do not have the fine scale resolution that is needed to address this issue. In contrast, sample...

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Publication status:
Published

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Publisher copy:
10.1111/1467-9868.00355

Authors


Fearnhead, P More by this author
Donnelly, P More by this author
Volume:
64
Issue:
4
Pages:
657-680
Publication date:
2002
DOI:
EISSN:
1467-9868
ISSN:
1369-7412
URN:
uuid:f0111473-73b2-4f8d-a14e-5c724396339c
Source identifiers:
50026
Local pid:
pubs:50026

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