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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

Abstract:
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
Publication status:
Published

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Publisher copy:
10.1038/ng2061

Authors


Barrett, JC More by this author
Prescott, NJ More by this author
Tremelling, M More by this author
Anderson, CA More by this author
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Journal:
Nature genetics
Volume:
39
Issue:
7
Pages:
830-832
Publication date:
2007-07-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:f009b13b-5471-43b5-8858-be5ec4b8d2d1
Source identifiers:
135634
Local pid:
pubs:135634

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