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5-(123)I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment.

Abstract:

Treatments currently licensed for Alzheimer's dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of illness and treatment suitability. In this pilot, we examined nine patients with amnestic mild cognitive impairment (MCI) and 10 age and education matched healthy volunteers with high resolution SPECT and the nicotinic receptor ligand 5-(123)I-A-85380. Uptake data were analysed using voxel-based techniques for group comparisons and regressi...

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Publication status:
Published

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Journal:
Neurobiology of aging
Volume:
31
Issue:
11
Pages:
1885-1893
Publication date:
2010-11-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:f00890bf-7f23-44cf-9e86-f2e8c5c6411a
Source identifiers:
139229
Local pid:
pubs:139229

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