A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

Journal article

Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution. Recent extensive genome-wide association studies (GWASs) have identified numerous single nucleotide polymorphisms associated with obesity, but these loci together account for only a small fraction of the known heritable component. Thus, the 'common disease, common variant' hypothesis is increasingly coming under challenge. Her...

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Authors: Walters, R; Jacquemont, S; Valsesia, A; de Smith, A; Martinet, D

• Publication status: Published
• Journal: Nature
• Volume: 463
• Issue: 7281
• Pages: 671-675
• Publication date: 2010-02-01
• DOI: 10.1038/nature08727
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Genome-Wide Association Study; Mutation; Reproducibility of Results; Cognition Disorders; Female; Inheritance Patterns; Cohort Studies; Adult; Male; Body Mass Index; Obesity; Heterozygote; Child; Young Adult; Chromosome Deletion; Humans; Case-Control Studies; Chromosomes, Human, Pair 16; Sex Characteristics; Aging; Age of Onset; Europe; Penetrance; Adolescent