Systems-level feedback in cell-cycle control.

Journal article

Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)-CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations...

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Authors: Novák, B; Vinod, P; Freire, P; Kapuy, O

• Publication status: Published
• Journal: Biochemical Society transactions
• Volume: 38
• Issue: 5
• Pages: 1242-1246
• Publication date: 2010-10-01
• DOI: 10.1042/bst0381242
• EISSN: 1470-8752
• ISSN: 0300-5127
• Language: English
• Keywords: Humans; Animals; Feedback, Physiological; Cell Cycle; Cell Cycle Proteins; CDC2 Protein Kinase; Cyclin B