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Journal article

Systems-level feedback in cell-cycle control.

Abstract:

Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)-CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations...

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Publication status:
Published

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Publisher copy:
10.1042/bst0381242

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Journal:
Biochemical Society transactions
Volume:
38
Issue:
5
Pages:
1242-1246
Publication date:
2010-10-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:eff0d7e0-c981-4ef5-b1ea-d78c5c39c71e
Source identifiers:
99840
Local pid:
pubs:99840

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